I installed WordPress using Fantatisco in my cpanel and created a blog. I want to create a second wordpress blog. Do I have to install WordPress again.
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About the Author: Read more about this and other topics related to never say never

That would be the easy way. Install it again – to a different subdirectory – and point it at a second database.
The below article will help you,
you have to have hosting for multiple domains available and then create a new folder for your new blog and then install the new wordpress script there.
for example:
public html/wordpress1/
public html/wordpress2/
script is in public html/wordpress1/
and
public html/wordpress2/
You must point your domain to the appropriate directories on your hosting, it’s easy but is hard to explain right here, you can contact me at my blog if you want.